Gender differences in serum markers of inflammation and platelet activation in patients with non-valvular atrial fibrillation

The prevalence of atrial fibrillation is high and comparable in both sexes. Such factors as differently expressed blood biomarkers women men may play a role the occurrence development thrombotic complications. To study markers inflammation platelet activation patients with non-valvular origin, receiving anticoagulant therapy having history complications without complications, depending on gender patients. included 22 healthy volunteers 60 diagnosed therapy, which 21 developed Serum levels α2- macroglobulin, hsC-reactive protein, fetuin A, α-1-acid glycoprotein, L-selectin, serum amyloid P, adipsin, factor 4 were studied FLEXMAP 3D using Acute Phase diagnostic test systems Panel 3. A comparative content demonstrated an increased concentration C-reactive protein groups fibrillation; decrease L-selectin group thrombosis compared women. There no differences volunteers. level adipsin had volunteers, however, it was significantly thrombosis. exceeded value this indicator women; found fibrillation. Low simultaneous increase 4, lead to prothrombogenic potential change balance pro- antiinflammatory mediators towards female